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What Autophagy Actually Is & How to Break a Fast Without Regret

Dr. Ludidi explains the cellular repair process known as autophagy, plus what to eat (and avoid) when the fast ends.

If your goal with fasting goes beyond calorie restriction and autophagy or cellular repair is on the menu—this one’s for you.

In this final clip of the series, Samefko Ludidi, Ph.D., breaks down what autophagy actually is (hint: it’s not an on/off switch), how long it typically takes to initiate, and why the real power lies in what your body does without constant food input.

“Autophagy isn’t something you do, it’s something you allow your body to do.”

We also get into:

  • When autophagy tends to kick in (usually 20–24 hours)

  • How long fasts can realistically go before benefits diminish

  • The truth about bone broth during fasting (does it ruin everything?)

  • How to break a fast gently, based on your body's digestive needs

And if you're wondering whether you need a strict water-only fast to get the benefits? Ludidi offers a refreshingly realistic perspective:

“Everyday practice works quite differently from how the theoretical paradigm is built.”

No guilt. No perfection. Just a smarter way to approach metabolic health.


This wraps the series on intermittent fasting.
Thanks for following along! I'll be pulling a few more short clips from this final conversation over the next couple of weeks. If you're new here, catch the full series in the archive below.

📚 Full conversation and past clips

Next week, I’m shifting focus—from fasting to feeding.
We’ll dig into the science (and controversy) behind infant formula, nutrition, and toxic exposures most parents never hear about.

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